Endocrine Abstracts

Background: Nonclassic congenital adrenal hyperplasia (NCAH) is a condition associated with adrenal masses and suggested by current European guidelines to be considered in case of bilateral adrenal lesions. NCAH is caused by different mutations in the CYP21A2 gene coding for the 21-hydoxylase enzyme in the glucocorticoid synthesis leading to mild cortisol deficiency and elevated androgen and steroid precursor levels. 17-hydroxyprogesterone (17OHP) is the most importan...

Background: Resource-saving and medically safe investigations of adrenal incidentaloma (AI) is one of the challenges in modern endocrinology. The absolutely majority of AIs are benign and hormonally inactive. Mild hypercortisolemia is the most common finding in hormonally active AI and is often referred to as subclinical Cushing syndrome (SCS). SCS is associated with increased risk of type 2 diabetes, poorly regulated hypertension, osteoporosis and cardiovascular disease. Ther...

Background: Adrenal incidentalomas (AI) are common and reported at frequencies of 2-10% at CT-scans of the abdomen. It is established that the number of diagnosed and investigated cases of AI have increased over the last decades. This increase is closely related to the development of modern radiology. General access of CT scanners with higher performance have led to an improved capacity and consequently more performed investigations. Other contributing factors are improved ima...

Objective: Preoperative iodine therapy due to toxic nodular goiter (TNG) is discouraged as iodine may cause an aggravation of hyperthyroidism. In Graves’ disease iodine has been used for a century but little data is available on iodine treatment in TNG. We aimed to examine if a short course of iodine treatment is safe to administer in TNG.Method: 20 patients with TNG with persistent subclinical to mild hyperthyroidism were included at our tertiary c...

Background: It is not known if non-functional adrenal adenomas (NFAA) are associated with increased mortality.Objective: To investigate mortality in patients with NFAA and compare with matched controls. Design: Retrospective register-based national cohort study.Methods: Patients diagnosed with NFAA in Sweden 2005-2019 were identified and followed until death or 2020. For each case, four age/sex/municipality-m...

Background: The accuracy of the radiological and laboratory findings used to investigate adrenal masses are not optimal and therefore additional investigation methods, such as fine needle aspiration (FNA) are sometimes needed. Different methods are used for obtaining FNA such as endoscopic ultrasound (EUS), transabdominal ultrasound and computerized tomography (CT)-guided biopsy.Methods: Using a search function incorporated in our institutional pathology...

Background: Primary aldosteronism (PA) accounts for 5–10% of all hypertension. In about 30% of PA patients the disease is unilateral caused by an adenoma or rarely unilateral hyperplasia. Cure rate from unilateral adrenalectomy, defined as normalized aldosterone secretion, is high but only 30–35% will obtain complete resolution of hypertension. We have studied pre- and postoperative characteristics potentially important for biochemical cure and normotension after adr...

Background: There have been conflicting reports on fertility, reproduction rates and pregnancy outcomes in women with congenital adrenal hyperplasia (CAH). Identification of potential modifiable influential factors of pregnancy outcomes in these women has been hampered in the past by either small sample sizes or data derived from epidemiological samples.Methods: Retrospective multi-center study including a total number of 72 women with CAH (n=34...

Background: Only few cases of patients with adrenal disorders affected by coronavirus disease 2019 (COVID-19) have been reported so far. In this study, clinical outcome data of patients with adrenal disorders and COVID-19 infection has been collected by the ESE Rare Disease Committee and ENDO-ERN via the European Registries for Rare Endocrine Conditions (EuRRECa) project.Methods: This questionnaire included 32 questions on collecting quantitative and qua...

Background: Congenital adrenal hyperplasia (CAH) and long-term glucocorticoid treatment may be associated with an increased risk of developing cardiometabolic sequelae such as abnormal glucose homeostasis, hyperlipidaemia, hypertension, cardiovascular (CV) disease, obesity and osteoporosis.Objectives: To study the current practice amongst expert centres for assessing cardiometabolic outcomes in adult patients with 21-hydroxylase CAH and to assess the pre...